Hydroxyethylcellulose-g-poly(lactic acid) blended polyurethanes: Preparation, characterization and biological studies

Abstract

The present research project is planned to prepare novel biodegradable and biocompatible hydroxyethylcellulose-g-poly(lactic acid) (HEC-g-PLA) blended polyurethanes. Hydroxyl terminated polybutadiene (HTPB) was reacted with isophorone diisocyanate (IPDI) to produce NCO-terminated polyurethane prepolymer and extended further by varying the mole ratio of chain extenders (HEC-g-PLA and BDO). The synthesized polyurethane samples were characterized by using Fourier Transform Infrared (FTIR), proton solid-state NMR (1H SS NMR) and X-ray diffraction (XRD). Thermal behavior of synthesized samples was checked by using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Biological behavior of the synthesized PU samples was also tested by various biological activities which showed much dependence on the mole ratio of chain extenders. Results indicated that incorporation of grafted HEC in to the polyurethane backbone leads to improvement in antibacterial activity, anti-biofilm inhibition, biocompatibility and non-mutagenicity.