Abstract

The aim of thisstudy was tocompare the effects of HES 200/0.5 and gelatin in the kidneys with a dose of < 20 ml/kg/day. This is an observational study conducted in patients who underwent elective surgery at Dr. Soetomo Hospital with the bleeding condition being 15-30% of EBV (Estimated Blood Volume) and a resuscitation fluid of HES 200/0.5 or modified fluid gelatin. The observed parameters were the ratio of NAG/urinary creatinineand serum creatinine. The results indicated that there was a significant increase in the NAG/creatinine ratio in the HES 200/0.5 group (p = 0.0004), with no significant increase in modified gelatin. By contrast, the gelatin group showed a significant increase in serum creatinine (p < 0.0001 ) compared with the HES group. However, the increase in the NAG/urinary creatinine ratio and serum creatinine in both groups was within the normal limits. HES 200/0.5 or modified gelatin at a dose of < 20 ml/kg/day in surgery patients does not lead to changes in kidney function

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