Abstract
The composition and content of hydroxycinnamic (HCA) and organic (OA) acids were investigated by HPLC with UV detection in Voronovs snowdrop (Galanthus woronowii Losinsk.) and common snowdrop (Galanthus nivalis L.) crude herbal drugs. G. woronowii HCA composition is presented by neochlorogenic, chlorogenic and criptochlorogenic acids. Neochlorogenic acid is absent in G. nivalis, but G. nivalis also contains chlorogenic and criptochlorogenic acids. The total HCA content in G. woronowii was 84.1 ± 6.7 mg / 100 g, and in G. nivalis 62.0 ± 5.0 mg / 100 g (0.06-0.08%). OA profile of two snowdrop species is presented by succinic, oxalic and malic acids. The total OA content in G. woronowii was 237.7 ± 2.4 mg / 100 g, and in G. nivalis 405.1 ± 4.7 mg / 100 g (0.2-0.4%). The obtained data concerning minor specific biologically active substances composition can be used in the standardization and activity evaluation of drugs produced from snowdrops.
Highlights
The composition and content of hydroxycinnamic (HCA) and organic (OA) acids were investigated by HPLC with UV detection in Voronov’s snowdrop (Galanthus woronowii Losinsk.) and common snowdrop (Galanthus nivalis L.) crude herbal drugs
G. woronowii HCA composition is presented by neo chlorogenic, chlorogenic and cryptochlorogenic acids
Neo chlorogenic acid is absent in G. nivalis, but G. nivalis contains chlorogenic and cryptochlorogenic acids
Summary
Snowdrop (Galanthus L.) genus comprises herbaceous ephemeroid bulbous plants of the Amaryllidaceae J.St.Hilfamily, it includes about 19 species and 2 hybrids of natural origin (World Checklist of Selected Plant Families). Voronov’s snowdrop (Galanthus woronowii Losinsk.) and common snowdrop (Galanthus nivalis L.) are most abundant in Russia (Bokov et al, 2015). Snowdrops became widely known thanks to the containing a number of Amaryllidaceae alkaloids, other groups of biologically active substances (BAS) remain poorly investigated. Snowdrops BAS complex, containing organic and hydroxycinnamic acids, Bokov et al / Journal of Applied Pharmaceutical Science 7 (02); 2017: 036-040. Worth noting is that succinic acid plays a special role, it is a universal intermediate metabolite in the Krebs cycle. Succinic acid exhibits antioxidant properties, has anti acidosic and anti-hypoxic action, being a natural factor of multifactor resistence of the body. Succinate ion is found in all cells capable for aerobic respiration while generating capacity of ATP synthesis at the oxidation of succinic acid is much higher than in a oxidation of any other substrate (Wiesner et al, 1986)
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