Abstract
Sol-gel method was employed for the preparation of strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBG NPs). These NPs have the size of 50 ± 5 nm, a pore size of 8.2 nm, and a surface area of 379 m2/g. Biocompatibility was confirmed by MTT and tissue histopathology in Balb/c mice. 5-Fluorouracil (5-Fu) was loaded to obtain Fu-Sr-MBG NPs which posed substantial inhibitory effects on the viability of the cancer cells (AGS). The amount of released drug was controlled by changing the pH of release medium. Formation of hydroxycarbonate apatite (HCA) was evaluated in simulated body fluid (SBF) and confirmed by XRD and FTIR. Thus a multipurpose nano-biomaterial was prepared and screened.
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