Abstract

Background: The difficulty of eliminating bacteria infecting bone tissue during bone healing treatments or surgery makes it desirably to develop solid scaffolds capable of sustained release of antibiotics to achieve the regeneration of the damaged tissue. Methods: With this function in view, in this work we prepared HA scaffolds functionalized with1,2- Hydroxypropyl-β-Cyclodextrin to increase the loading and sustained release for ciprofloxacin. Results: The lowest amount of CD was sufficient to fabricate HA functionalized microparticles and allowing for the CPX loading to be increased more than 40 times with respect to the non-functionalized HA particles. Spray-drying process rendered spherical particles with irregular surface that improved the release and the solubility of low soluble CPX in pH 7.4 medium in form of free drug and cyclodextrin complexes although free cyclodextrins were also released to the medium. Conclusion: It is concluded that the synthesized microparticles based on HA functionalized with Hydroxypropyl -β-Cyclodextrin merit further investigation to be used as platform for delivering antibiotics in bone regeneration.

Highlights

  • The administration of antibiotics during bone regeneration process to prevent infection and to accelerate bone healing has been extensively used

  • It is concluded that the synthesized microparticles based on HA functionalized with Hydroxypropyl -β-Cyclodextrin merit further investigation to be used as platform for delivering antibiotics in bone regeneration

  • An approach based on hydroxyapatite functionalized with cyclodextrins for the loading and release of an antibiotic drug has been developed with bone regeneration purposes

Read more

Summary

Introduction

The administration of antibiotics during bone regeneration process to prevent infection and to accelerate bone healing has been extensively used. The localized delivery of antibiotics is severely limited by the high and sustained concentrations of antibiotic that is required in the injured bone tissue. To address these shortcomings, the administration of antibiotics, like ciprofloxacin, from implantable and biodegradable platforms may allow their controlled release, thereby, augmenting the efficacy. Bone regeneration consists in the formation of new bone after a process of remodeling and constitutes a complex physiological phenomenon that can occur during the repair of fractures. Other diseases involving the bone regenerative process may be the avascular necrosis, atrophic pseudarthrosis, or the severe osteoporosis These situations may be managed using bone grafting and bone tissue engineering. These bacterial colonies are very difficult to treat, since microorganisms become more resistant when attached to biological materials [3]

Objectives
Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call