Abstract
Abstract The aim of this study was the synthesis of composites containing hydroxyapatite (Hap) or silicon substituted hydroxyapatite (HapSi), carboxyl functionalized carbon nanotubes (fMWCNT) and gelatin (G) in different ratios. Ibuprofen (IBU) was chosen as a model drug for the formulation of extended-release dosage forms. The obtained composites were characterized using X-ray diffraction, laser diffraction particle size analyzer, Brunauer-Emmett-Teller surface area measurements, transmission electron microscopy and Fourier transformed infrared spectroscopy. IBU adsorption and desorption was monitored by UV-VIS spectroscopy. The obtained results revealed that composites containing three components exhibit higher adsorption efficiency (Hap-fMWCNT-20G - 82.7% and HapSi-fMWCNT-20G - 84.6%) and extended-release of IBU, due to the chemical bonds between the carboxyl groups of IBU and the functional groups on the composite surface. The adsorption capacity of Hap composites is important for dental or orthopedic implants, the anti-inflammatory substances being adsorbed on their surface; but the adsorption capacity also enhances new bone formation (osteosynthesis) around the implants. These composites are thus attractive materials to be used in bone tissue engineering and drug delivery systems.
Highlights
One of the challenges of modern medicine is the development of new materials that can mimic human tissue in order to minimize the risk of rejection by the human body [Constanda et al, 2016]
The carboxyl-functionalized carbon nanotubes (CNTs) have similar features and size with nanoscale collagen fibers of human bones, while the gelatin (G) has the same chemical composition but requires the help of reinforcement filler [Chao et al, 2015]. Due to their high specific surfaces and biocompatibility, the G/carboxyl-functionalized CNTs composites can be used as drug delivery systems [Yoon et al, 2014]
Materials All reagents were of analytical grade (Merck, Germany) and used as received without further purification, except gelatin that was purchased from Sigma-Aldrich, Germany. fMWCNTs with specific surface of 30 m2/g and pore volume of 0.1 cm3/g were synthetized by chemical vapor deposition technique according to Barabas et al (2015)
Summary
One of the challenges of modern medicine is the development of new materials that can mimic human tissue in order to minimize the risk of rejection by the human body [Constanda et al, 2016]. In order to improve the mechanical properties and to increase the corrosion resistance of Hap or HapSi, its structure must be reinforced with various materials such as carbon nanotubes (CNTs), TiO2 or ZrO2 [Barabas et al, 2015; Park et al, 2018]. The carboxyl-functionalized CNTs have similar features and size with nanoscale collagen fibers of human bones, while the gelatin (G) has the same chemical composition but requires the help of reinforcement filler [Chao et al, 2015]. Due to their high specific surfaces and biocompatibility, the G/carboxyl-functionalized CNTs (fMWCNT) composites can be used as drug delivery systems [Yoon et al, 2014]
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