Abstract
Hydroxamic acid containing organic molecules display strong metal ion chelating property, and therefore used as metalloenzyme inhibitors. They display strong affinity toward histone deacetylase, matrix metalloproteinases, human epidermal growth factor receptor-2, and tumor necrosis factor alpha converting enzyme. These enzymes play crucial roles in the pathogenesis of cancer and are attractive targets for the development of new anticancer agents. Various molecules bearing free hydroxamic acid at one terminal have been synthesized and evaluated for their activities. This article will focus on the development of various classes of hydroxamic acid-based metalloenzyme inhibitors and anticancer agents.
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