Abstract

Hydroxamic acid containing organic molecules display strong metal ion chelating property, and therefore used as metalloenzyme inhibitors. They display strong affinity toward histone deacetylase, matrix metalloproteinases, human epidermal growth factor receptor-2, and tumor necrosis factor alpha converting enzyme. These enzymes play crucial roles in the pathogenesis of cancer and are attractive targets for the development of new anticancer agents. Various molecules bearing free hydroxamic acid at one terminal have been synthesized and evaluated for their activities. This article will focus on the development of various classes of hydroxamic acid-based metalloenzyme inhibitors and anticancer agents.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.