Abstract
Hydrotropic solubilization of total boswellic acids from Boswellia serrata gum resins has been investigated with aqueous solutions of alkylbenzene sulfonate hydrotropes. Due to their amphiphilic structures, the hydrotropes cooperatively form microassemblies in aqueous solutions which, in turn, are responsible for the solubilization of water-insoluble organic substances. The solubility of boswellic acids was increased by 2 orders of magnitude in the presence of hydrotropes in aqueous solutions. The effect of hydrotrope concentration on the solubility was investigated in detail along with the kinetics of solubilization. The selectivity toward boswellic acids over other terpene compounds was investigated by molecular modeling using the AMBER94 force field.
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