Abstract
Irbesartan (IB) is a water insoluble drug belonging to BCS II that exerts its anti-hypertensive effect through the blockage of angiotensin II receptors. The aqueous insolubility of IB limits its bioavailability and overall efficacy. Hydrotrophy, a solubilization technique to achieve an augmentation in aqueous solubility of poorly water-soluble drugs, has recently gained a lot of interest due to its safety, economics, and use of non-toxic and non-flammable adjuvants. The present study deals with application of hydrotrophy techniques to increase the solubility of IB using sodium benzoate and urea as the hydrotropic agent. The results showed a significant enhancement in dissolution profile of IB as compared to non-hydrotropic drug. The dissolution rate and solubility comparison of both hydrotropic agents revealed that sodium benzoate has a better solubilizing efficiency than urea. Hence, it can be concluded that hydrotropic concept can be adopted as a solubility enhancement technique for poorly water-soluble drugs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
