Abstract
The hydrothermal reaction of ciprofloxacin ( 1) with Cu(BF 4) 2·6H 2O yields a copper complex having a molecular formula, [Cu(cf) 2(BF 4) 2]·6H 2O (cf = ciprofloxacin), which is characterized by spectroscopic and electrochemical measurements as well as single crystal X-ray studies [ a=9.1079(13), b=9.6112(16), c=11.4542(18) Å, α=90.518 (19)°, β=99.160 (18)°, γ=93.315 (19)°, P1bar, Z=1]. The F 2O 4 donor atom set forms a (4+2) distorted octahedral geometry around the central copper atom; which has a highly facile copper redox couple (+0.23 V). The copper conjugate exhibits a significant enhancement in the antitubercular activity probably arising out of its rapid intracellular reduction leading to oxygen activation, which is detrimental to the mycobacteria.
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