Abstract
3D‐printed bioceramics derived from silicone resin are of great interest in bone tissue engineering owing to their simple processes and low cost. Herein, PCN‐224, as a subclass of metal−organic frameworks (MOFs), is successfully fabricated and deposited on the surface of 3D‐printed porous β‐Ca2SiO4 (C2S) scaffolds. The composite scaffolds possess uniform interconnected macropores (≈400 μm), with increased porosity and slower degradation. The results indicate that deposition of PCN‐224 significantly promotes cell proliferation and the expression of osteogenesis‐related genes. Moreover, the composite scaffolds significantly improve calvarial defect healing in rats, compared with C2S scaffolds. Therefore, the PCN‐224‐modified 3D‐printed porous C2S composite scaffolds are promising candidates for bone tissue engineering.
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