Abstract
Bioactive glasses (Bioglasses) are widely synthesized by the conventional sol-gel method consisting of two main steps for sol and gel formation. However, the conversion from sol to gel requires a long time (5–7 days). In this study, the hydrothermal system was used to quickly synthesize the bioactive glass by reducing the conversion time from sol to gel. The hydrothermal assisted conventional sol-gel method was applied for synthesis of the bioactive glass 70SiO2–30CaO (mol%) (noted as 70S30C). The synthetic glass was investigated by the physical-chemical techniques. The ‘‘in vitro’’ experiments in SBF (Simulated Body Fluid) solution was also performed to evaluate the bioactivity of synthetic material. The obtained results show that the bioactive glass 70S30C was successfully elaborated by using the hydrothermal assisted conventional sol-gelmethod. The consuming time was reduced compared to the conventional method. The physical-chemical characterization confirmed that the synthetic glass is amorphous material with mesoporous structure consisting of interconnected particles.The specific surface area, pore volume and average pore diameter of synthetic glass were 142.8 m2/g, 0.52 cm3/g, and 19.1 nm, respectively. Furthermore, synthetic bioactive glass exhibited interesting bioactivity when immersed in simulated body fluid (SBF) solution for 1 days and good biocompatibility when cultured in cellular media.
Highlights
In the past fifty years, bioactive glasses have been developed and applied as artificial bone materials used as components in dental filling, implants, and bone grafting in orthopedic surgery to restore and repair damaged and diseased bones [1,2]
Their bioactivity is shown by the formation of a new layer of hydroxyapatite Ca10(PO4)6(OH)2 (HA) on the surfaces when they are implanted in defective and broken bone positions in the human body
The second one with an endothermic peak at 492.6 °C is characteristic of the decomposition of NO3- groups [10]
Summary
In the past fifty years, bioactive glasses (bioglasses) have been developed and applied as artificial bone materials used as components in dental filling, implants, and bone grafting in orthopedic surgery to restore and repair damaged and diseased bones [1,2] Their bioactivity is shown by the formation of a new layer of hydroxyapatite Ca10(PO4)6(OH) (HA) on the surfaces when they are implanted in defective and broken bone positions in the human body. The method can quickly prepare glass systems in large quantities It requires synthesis processes at high temperatures (above 1350 °C) where volatile components such as P2O5 can be escaped, resulting in deviations in the composition of synthetic bioglasses; obtained materials often have low values of specific surface area [7]. Variable synthesis processes can bring new properties of synthetic glass systems
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