Hydrotalcite combined with proton pump inhibitor in treatment of post endoscopic submucosal dis- section nicer： a randomized,controlled clinical trial

Abstract

Objective To evaluate the therapeutic efficacy of a combination of proton pump inhibi- tor（PPI） and hydrotaleite for endoscopic submucosal dissection （ESD） induced ulcer. Methods Eighty- one consecutive patients who underwent ESD were randomly assigned to either the group of PPI and hydrotal- cite therapy （drug combination group, n = 41 ） or the PPI group （n = 40）. Delayed bleeding rates were mo- nitored and compared. The main upper abdomen symptoms 1-wk later and ulcer healing rates and ulcer diam- eter 4-wk later were compared between the two groups. Results There was no significant difference in de- layed bleeding rate （ P 〉 0. 05 ）. At the end of first week after ESD, the combination therapy was significant- ly more effective than the PPI alone in reducing frequencies and severity of upper abdominal pain and upper abdominal distention, while there was no significant difference between the two groups in relieving belch and nausea. A better ulcer healing rates and a smaller ulcer diameter were observed in the combination group at the end of 4 weeks （P 〈 0. 05 ）. Conclusion The combination therapy of hydrotalcite and PPI can relieve upper abdominal symptoms and improve the healing rate of ESD induced ulcer. Key words: Ulcer, artificial; Endoscopic submucosal dissection; Hydrotalcite ; Protonpump inhibitor