Abstract
Novel thermosensitive gel-containing polymersomes (hydrosomes) were prepared by incorporating poly( N-isopropylacrylamide), PNIPAAm, into polymersomes based on poly(ethylene glycol)-b-poly(d,l-lactide). These hydrosomes are potential novel carriers for anticancer drugs and proteins. Hydrosomes with a size of 100–200 nm as determined with high resolution SEM, were prepared by injecting a solution of the polymer and PNIPAAm in THF into water. Giant hydrosomes containing fluorescein labeled PNIPAAm were prepared using CHCl 3 as the organic phase. The presence of the gel inside the polymersomes was shown by confocal laser scanning microscopy. Release of fluorescein isothiocyanate tagged dextran (FD, FITC-dextran, Mw 4000 g/mol) reveals that hydrosomes have acquired a more sustained release profile in comparison with empty polymersomes at 37 °C for 30 days, with low initial burst effect.
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