Abstract
Contact hypersensitivity (CHS) is characterized by the percutaneous penetration of a low molecular weight hapten and the cross-talk between lymphocytes and antigen-presenting cells. Following our investigations into the role of reactive nitrogen species (RNS) in this process, we have now studied the effect of three phenolics obtained from Phagnalon rupestre (Asteraceae) on CHS. The three compounds, which have previously been described as inhibitors of peroxynitrite reactivity, are 2-isoprenylhydroquinone-1-glucoside (IHG), 3,5-dicaffeoylquinic acid (DCA) and 3,5-dicaffeoylquinic acid methyl ester (DCE) [1]. The experimental design begins with the sensitization with oxazolone on abdominal mouse skin followed by the subsequent elicitation with the same agent on the ear five days later [2]. Inflammation end points include histological analyses and determination of the presence of cytokines, 3-nitrotyrosine and inducible NO synthase (iNOS). Dunnett's t values measures statistical significance.
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