Hydrophobicity Study for Some Pyrazolo‐Pyridine Derivatives by RP‐TLC and RP‐HPLC

Abstract

The hydrophobicity of thirteen 1H‐pyrazolo[3,4‐b]pyridine derivatives was studied by reversed‐phase thin layer chromatography (RP‐TLC) and reversed‐phase high performance liquid chromatography (RP‐HPLC). The partition coefficient log P value was measured for the unsubstituted derivative (8) using the classical shake flask method. The remaining compounds were the log P values calculated from 8 by Hansch‐Fujita hydrophobicity fragmental constant, π. The RM and log K parameters obtained by chromatography techniques were validated by comparison with those obtained from log P of 8 and, also, the log P calculated using the CLOGP computed software.