Abstract
Myricetin (Myr) is a phytochemical with many functional properties. However, its hydrophobicity, low bioavailability, and stability limit its application. In this study, octadecanoate oat β-glucan (OGE) was synthesized and gained recognition as a self-assembled micelle forming a polymer with a critical micelle concentration (CMC) of 59.4 μg/mL. The Myr-loaded OGE micelle was then prepared and characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), X-ray diffractometer (XRD), and Fourier-transform infrared spectroscopy (FT-IR) spectra. The water solubility of Myr was greatly enhanced by forming the Myr/OGE inclusion complex. Consequently, compared to free Myr, the retention of Myr in Myr-loaded OGE micelle was effectively increased during the intestinal digestion phase, and its antioxidant activity was also improved. Overall, our findings demonstrated the potential applications of OGE polymer for the development of prospective micelle in health food, cosmetics, and pharmaceutical fields because they can aid in the delivery of hydrophobic functional compounds like Myr.
Highlights
Myricetin (Myr) is a natural bioflavonoid that widely exists in plants, including tea, berries, fruits, vegetables, and medicinal herbs [1]
Our findings demonstrated the potential applications of OGE polymer for the development of prospective micelle in health food, cosmetics, and pharmaceutical fields because they can aid in the delivery of hydrophobic functional compounds like Myr
Data confirmed the presence of hydrophobic aliphatic modification of native β-glucan in OGE while keeping the poly-glucose backbone (The date was presented in Supplementary Materials)
Summary
Myricetin (Myr) is a natural bioflavonoid that widely exists in plants, including tea, berries, fruits, vegetables, and medicinal herbs [1]. It possesses a wide range of biological activities, such as antioxidant [2], anticancer [3], antidiabetic [4], and anti-inflammatory activities [5]. Its poor water solubility and susceptibility to degradation at high temperatures or certain pH are the most major challenges in utilizing its full potential [6] To overcome these issues, different delivery carriers were used to achieve controllable Myr release. There is a need to develop better-tolerated and less toxic carriers for Myr delivery
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