Abstract
Abstract The hydrophobic and the hydrophilic surface areas of seven kinds of monosaccharide molecules were calculated by using Hermann’s method. The hydrophobic indexes (Index A and Index B) which are defined as the ratio of the hydrophobic and the hydrophilic surface areas of the molecule are clearly correlated with the partition coefficient of monosaccharide between polystyrene gel and water, and the free energy change of transfer of monosaccharide from water to 1-butanol, indicating that the fraction of the hydrophobic surface area plays an important role in the interaction of monosaccharides and hydrophobic solutes in water.
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