Hydrophilic-hydrophilic mixed micellar system: effect on solubilization of drug

Abstract

Mixed micellar systems have been tried with the aim of achieving higher solubility of drugs compared to single micellar systems. Hydrophobic-hydrophilic mixed micellar systems have been used for the above purpose for the drug ciprofloxacin in the past. In the present study, a hydrophilic-hydrophilic binary micellar system comprising of pluronic copolymers pluronic F127 and pluronic L64 has been studied for its effect on solubilization of the drug Ciprofloxacin. The solutions of the two individual pluronic and their mixed micellar system with drugs were subjected to characterizations viz. UV-spectrophotometry, fluorimetry, FT-IR, dynamic light scattering (DLS), rheology, and partition coefficient. The mixed pluronic–drug system displayed greater solubility of the drug compared with the neat pluronic-drug systems in most of the characterizations. New C–OH bond formation was evidenced by FT-IR spectra due to drug micelle interaction. The values of free energy changes of micellization were found to be −25 kJ mol−1 for pluronic F127, −74.5kJmol−1 for L-64, and −170.4 kJ mol−1 for the mixed pluronic. This is suggestive of spontaneous and stronger binding of drug ciprofloxacin with mixed pluronic in comparison with that in single micellar systems.Graphic abstract