Abstract
Hydrophilic silica/copolymer nanoparticles of SiO2-g-P(PEGMA)-b-P(PEG) are prepared by silica surface-initiating atom transfer radical polymerization (SI-ATRP) of poly (ethylene glycol) methyl ether methacrylate (PEGMA) and poly(ethylene glycol) methacrylate (PEG), by using Three molar ratios of SiO2-Br/PEGMA/PEG as 1/42.46/19.44, 1/42.46/38.88 and 1/42.46/77.76. Their temperature sensitive behaviour, pH response and surface properties as protein-resistance coatings are characterized. 220 nm core-shell nanoparticles as P(PEGMA)-b-P(PEG) shell grafted on SiO2 core are formed in water solution, which gained LCST at 60。C - 77。C and good dispersion in water when pH > 5.0. The water-casted films by SiO2-g-P(PEGMA)-b-P(PEG) obtain a little rough surface (Ra = 26.8 - 29.7 nm). While, the introduction of P(PEG) segments could slight increase the protein-repelling adsorption of SiO2-g-P(PEGMA)-b-P(PEG) films (△f = ?6.96 Hz ~ ?7.25 Hz) compared with SiO2-g-P(PEGMA) films (△f = ?9.5 Hz). Therefore, SiO2-g-P(PEGMA)-b-P(PEG) could be used as protein-resistance coatings.
Highlights
Hydrophiphilic block copolymers are mostly used in biological sciences [1] [2] and advance material [3]
The significant hydrophiphilic block copolymers are mainly used poly (poly methyl ether methacrylate, P (PEGMA), or poly (poly methacrylate, P(PEG), as the hydrophilic block [4]-[7]. Both P(PEGMA) and P(PEG) consist of a linear methacrylate backbone reactive functional group with a side chain of poly(ethylene glycol) (PEG), which could generate a wealth of new polymeric materials by employing the recently developed living radical polymerization techniques of reversible addition fragmentation chain transfer (RAFT) [8] [9] and atom transfer radical polymerization (ATRP) [10]-[12]
This paper reports the synthesis, the tem-responsive and surface properties as protein-resistance coatings of the hydrophiphilic silica graftedblock copolymers of SiO2-g-P(PEGMA)-b-P(PEG) nanoparticles, which are synthesized via surface-initiating atom transfer radical polymerization (SI-ATRP) approach by poly [poly methyl ether methacrylate)] and (P(PEGMA)) poly (poly methacrylate, P(PEG)) in three molar ratios of SiO2-Br/PEGMA/12FMA = 1/42.46/19.44, 1/42.46/38.88 and 1/42.46/77.76
Summary
Hydrophiphilic block copolymers are mostly used in biological sciences [1] [2] and advance material [3]. This paper reports the synthesis, the tem-responsive and surface properties as protein-resistance coatings of the hydrophiphilic silica graftedblock copolymers of SiO2-g-P(PEGMA)-b-P(PEG) nanoparticles, which are synthesized via SI-ATRP approach by poly [poly (ethylene glycol) methyl ether methacrylate)] and (P(PEGMA)) poly (poly (ethylene glycol) methacrylate, P(PEG)) in three molar ratios of SiO2-Br/PEGMA/12FMA = 1/42.46/19.44, 1/42.46/38.88 and 1/42.46/77.76. Their chemical structures are characterized by nuclear magnetic resonance (1H-NMR) spectroscopy, Fourier transform infrared spectroscopy (FI-IR) and thermo gravimetric analysis (TGA). The obtained results provide a prospected insight on the application of SiO2-g-P(PEGMA)-b-P(12FMA) nanoparticles as protein-resistance coatings
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