Abstract
The aim of the present review was to provide recommendations on the use of hydrolysates in infants when formula feeding is initiated. We performed an overview of reviews followed by a systematic review of subsequently published trials. We found 8 systematic reviews; only 1 study of limited quality was published afterwards. Certain extensively hydrolyzed casein and certain partially hydrolyzed whey formulas are appropriate for reducing the risk of allergy in infants at high risk when formula feeding is initiated. In high-risk infants, when breast-feeding is not possible, hydrolysates of documented safety and efficacy have an indication in infant feeding up to the age 4 to 6 months.
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