Abstract
A azamacrocyclic compound with carboxyl branch, 5,5,7,12,12,1-hexamethy-1,4 ,8,11-tetraazacyclo- tetradecane-N/-acetic acid(L), and its neodymium complex ware synthesized and characterized. The mode of combination of the neodymium complex with DNA was investigated by UV-vis absorption spectroscopy methods. The cutting function of the neodymium complex to supercoiled DNA was studied by gel electrophoresis method. The results show that metal complex can bind to the phosphate of DNA double helix and promote the hydrolysis of phosphodiester bond of supercoiled DNA(Form I); Supercoiled form DNA was transformed into nicked form DNA(Form II) with strong cutting effect of the macrocyclic neodymium complex; the reaction of DNA cut is completed by a hydrolysis mechanism.
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