Abstract
An in vitro method was developed for estimating in vivo degradation time of sutures made from synthetic bioresorbable polyesters. Model compounds and a number of commercially available bioresorbable suture products were used to establish the applicability of this hydrolysis profile methodology. Hydrolysis profiles on tested bioresorbable sutures were determined as a function of size and chemical composition. This method of accelerated absorption testing may shorten product development time and reduce the need for animal testing. In addition, the methodologies presented have the potential to provide insight into the loss of mechanical properties with time.
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