Hydrolysis products of cisplatin: pK a determinations via[1H, 15N] NMR spectroscopy

Abstract

The pKa values of cis-[PtCl(H2O)(NH3)2]+(6.41) and cis-[Pt(H2O)2(NH3)2]2+(5.37 and 7.21) have been determined at 300 K via the use of 15N-edited 1H NMR spectroscopy and [1H, 15N] heteronuclear multiple quantum coherence spectroscopy; this allows rapid measurements at low (millimolar) concentrations, and so avoids some of the problems associated with other methods.