Abstract
We report a series of dual-stimuli-responsive polymers based on a cyclic ketene acetal monomer, 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), which goes through radical ring-opening propagation to generate ester bonds constructing degradable backbones. Considering the significance of degradability in drug delivery system, there is an urgent need to design multi-functional platforms, while BMDO-based polymers are commonly related to be degraded in a single approach. Therefore, BMDO is firstly combined with a photo-labile monomer, o-nitrobenzyl methacrylate (NBM), to give the dual-degradable copolymers realizing the decomposition of main chains under an accelerated alkaline condition and the collapse of pendants by the UV light irradiation. The kinetics on the copolymerization of BMDO and NBM are investigated as they belong to less and more activated monomers, respectively. The copolymers and the degraded products are systematically characterized and analyzed, which has widened the insight of preparing BMDO-based degradable polymers.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have