Abstract
The hydrolysis of the [Pt(dien)H2O]2+ and [Pd(dien)H2O]2+ complexes has been investigated by potentiometry at 298 K, in 0.1 mol dm−3 aqueous NaClO4. Least-squares treatment of the data obtained indicates the formation of mononuclear and μ-hydroxo-bridged dinuclear complexes with stability constants: log β11 = −6.94 for [Pt(dien)OH]+, log β11 = −7.16 for [Pd(dien)OH]+, and also log β22 = −9.37 for [Pt2(dien)2(OH)2]2+ and log β22 = −10.56 for [Pd2(dien)2(OH)2]2+. At pH values > 5.5, formation of the dimer becomes significant for the PtII complex, and at pH > 6.5 for the PdII complex. These results have been analyzed in relation to the antitumor activity of PtII complexes.
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