Hydrolysis of O, O-dimethyl-2,2-dichlorovinyl phosphate (DDVP) by esterases in parasitic heliminths, and in vertebrate plasma and erythrocytes

Abstract

1. The hydrolysis of DDVP ( O, O-dimethyl-2,2-dichlorovinyl phosphate), E600 ( O, O- diethyl-4-nitrophenyl phosphate) and MeE600 ( O, O-dimethyl-4-nitrophenyl phosphate) was measured in homogenates of some parasitic heliminths, and in plasma, and liver of some vertebrates. 2. The proteins which hydrolysed DDVP in all studied preparations can be classified under arylesterases (EC 3.1.1.2).