Abstract
1,4-Dihydropyridines (DHPs) have been used in the reduction of carbon-carbon double bonds under microwave irradiation without solvent. The efficiency of the reactions is dramatically dependent on the steric effects in the DHPs and on the electronic effects in the olefins.
Highlights
Hantzsch 1,4-dihydropyridines (DHPs) continue to attract much attention because of their use as NAD(P)H models to probe the mechanism of hydrogen transfer [1,2,3] and their applications in medicine as calcium channel modulators, vasodilators and antihypertensive agents [4,5,6]
We wish to report our results on the synthesis of some 1,4-DHPs and their behavior under microwave irradiation in redox reactions with olefins, a system that has been poorly studied, contrary to the mimetic reduction of carbonyl compounds
Conventional heating has sometimes been replaced by microwave induced heating [8,9,10,11] but, surprisingly, this last procedure has never been used for the preparation of 4-unsubstituted derivatives
Summary
Hantzsch 1,4-dihydropyridines (DHPs) continue to attract much attention because of their use as NAD(P)H models to probe the mechanism of hydrogen transfer [1,2,3] and their applications in medicine as calcium channel modulators, vasodilators and antihypertensive agents [4,5,6]
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