Abstract
The protective effect of hydrogen (H2) on ROS-induced diseases has been proved by many researches, which demonstrated that through eliminating •OH and •ONOO–, H2 could effectively attenuate lipid and DNA peroxidation, improve cellular antioxidant capacity, and then protect cells against oxidant damage. Most of free radicals in human body are ROS, including O2•–,•OH, H2O2, NO•,•ONOO–, and so on. Under normal circumstances cells are able to maintain an adequate homeostasis between the formation and removal of ROS through particular enzymatic pathways or antioxidants. But under some pathological conditions, the balance is disturbed, leading to oxidative stress and various diseases, such as chronic obstructive pulmonary disease (COPD). Studies have shown that ROS played a pivotal role in the development of COPD and some antioxidants were effective in the protection against the damaging effects of oxidative stress. Therefore, we hypothesize that owing to its peculiarity to eliminate toxic ROS, hydrogen therapy may be a novel and effective treatment for COPD.
Highlights
Hydrogen (H2), a colorless, tasteless, odorless, non-irritating, and highly flammable diatomic gas, was generally regarded as physiologic inert gas in hyperbaric medicine
The importance of H2 immediately drew widespread concerns and it is proved to be effective for many ROS-related diseases, such as hepatic and cardiac hypoxia–ischemia injury, inflammation injury caused by small intestine transplantation and neonatal hypoxia–ischemia injury (Fukuda et al, 2007; Buchholz et al, 2008; Cai et al, 2008; Hayashida et al, 2008)
Other ways to administrate H2, such as drinking H2-saturated water, intraperitoneal and intravenous injection of H2-saturated saline, were effective to many disorders, such as cerebral hypoxia– ischemia injury, human type II diabetes, nephrotoxicity induced by cisplatin, Parkinson’s disease and atherosclerosis in apolipoprotein (Cai et al, 2009; Chen et al, 2009; Mao et al, 2009; Sun et al, 2009; Zheng et al, 2009; Oharazawa et al, 2010)
Summary
Faculty of Naval Medicine, Department of Diving Medicine, Second Military Medical University, Shanghai, People’s Republic of China. Reviewed by: Xia Liu, Second Military Medical University, China M. The protective effect of hydrogen (H2) on ROS-induced diseases has been proved by many researches, which demonstrated that through eliminating OH and ONOO−, H2 could effectively attenuate lipid and DNA peroxidation, improve cellular antioxidant capacity, and protect cells against oxidant damage. Under normal circumstances cells are able to maintain an adequate homeostasis between the formation and removal of ROS through particular enzymatic pathways or antioxidants. Studies have shown that ROS played a pivotal role in the development of COPD and some antioxidants were effective in the protection against the damaging effects of oxidative stress.we hypothesize that owing to its peculiarity to eliminate toxic ROS, hydrogen therapy may be a novel and effective treatment for COPD
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