Abstract
We have previously reported appreciable concentrations of hydrogen sulfide (H 2S) in paediatric amino-acid solutions, apparently formed from cysteine during the production process. Since manufacturers assured us of their aim to reduce the contents of the potentially toxic H 2S in these solutions, we determined whether lower amounts have been achieved 2 years after our first report. Median H 20S content of 13 paediatric amino-acid solutions was 22.8 μg/I (range: not detectable to > 280 μg/l which is comparable to the amounts previously found. Median H2S content of 8 special solutions for renal and hepatic disorders was 15.8 μg/I (range not detectable to > 280 μg/I). We conclude that manufacturers should make further efforts to reduce H2S amounts in parenteral amino-acid solutions.
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