Abstract
A super-porous hybrid platform can offer significantly increased number of reaction sites for the analytes and thus can offer advantages in the biosensor applications. In this work, a significantly improved sensitivity and selectivity of hydrogen peroxide (H2O2) detection is demonstrated by a super-porous hybrid CuO/Pt nanoparticle (NP) platform on Si substrate as the first demonstration. The super-porous hybrid platform is fabricated by a physiochemical approach combining the physical vapor deposition of Pt NPs and electrochemical deposition of super-porous CuO structures by adopting a dynamic hydrogen bubble technique. Under an optimized condition, the hybrid CuO/Pt biosensor demonstrates a very high sensitivity of 2205 µA/mM·cm2 and a low limit of detection (LOD) of 140 nM with a wide detection range of H2O2. This is meaningfully improved performance as compared to the previously reported CuO-based H2O2 sensors as well as to the other metal oxide-based H2O2 sensors. The hybrid CuO/Pt platform exhibits an excellent selectivity against other interfering molecules such as glucose, fructose, dopamine, sodium chloride and ascorbic acid. Due to the synergetic effect of highly porous CuO structures and underlying Pt NPs, the CuO/Pt architecture offers extremely abundant active sites for the H2O2 reduction and electron transfer pathways.
Highlights
Hydrogen peroxide (H2O2) is one of the most important elements in the field of biomedical, environmental analysis, textile and food manufacturing industries due to its strong oxidizing property [1]
The Rq and surface area ratio (SAR) were significantly increased as shown in Figure 2c after the formation of Pt NPs
A significantly improved H2O2 detection performance has been demonstrated by the uniquely designed super-porous hybrid nanostructures of CuO/Pt on Si fabricated by the combined physicochemical approach
Summary
Hydrogen peroxide (H2O2) is one of the most important elements in the field of biomedical, environmental analysis, textile and food manufacturing industries due to its strong oxidizing property [1]. It plays a crucial role as a signaling molecule in regulating various biological processes [2]. What is required is high sensitivity with a low limit of detection (LOD) along with good selectivity and a fast response. Electrochemical sensing [11] can offer one of the handiest approaches for the detection of H2O2 due to its high sensitivity, fast response, precision and simple operation. Os fbteene,nthdeeCmuOonlasyterrastewderfie rusttilitziemdefoirnththe iHs2wO2odrekt.ecFtiiognubruet1thcesphoorwouss tnhaenoesntreurcgtuyr-eds ispersive X-ray spectroof sCcuoOpbyy(EthDe dSy)nsapmeicctrhaydorfogCeunObu-b5bAlestaecmhnpilqeuewhiaths bteheen cdoemrroenssptroanteddinfirgstmtimapesi.n Tthhisewsuorpke. r-porous CuO/Pt hybFcroiigrdruerpsepl1oacntfsdohionrwmg smdtahepemse.noTenhrgesytsr-udapitseeprs-epraosirhvoeiugXsh-CrsaueyOns/psPiettcihtvryoibtsryciodoppfyl2a(Et2fDo0r5Sm)μsdpAeemc/mtroanMostf·rcCamtueOs2-af5oAhrigstahhmseepnHlesi2wtOiviti2htydthoeeftection as seen in Figu2,r2e051μdAa/mndM∙acnm2efxocretlhleenHt2Ose ldeecteticvtiiotnyaasgsaeeinn sint gFliguucroes1ed, farnudcatnoseex,cedlloenptasmeleincteiv,itsyoadgiauinmst chloride, citric acid agnludcoassec, forrubctiocsea,cdiodpaams icnlee,asroldyiusmeecnhloinridFei,gciutrricea1ceid. aInt dalassocosrbhicowacisdaasloclwearLlyOseDenoifn1F4ig0urneM with a wide detect1ieo.nIt raalsnogsheo. wTshaisloiws LthOeDfiorfs1t40dneMmwonitshtarawtiidoendoetfecstuiopnerra-npgoe.roThuiss iCs tuhOe finrsatndoemstornusctrtautiroensoafnd of the hybrid archssiuetnpesecirnt-ugp.roerowusitChutOhenaPntoNstrPusctuforerstahnedHof2Oth2e sheynbsriidnga.rchitecture with the Pt NPs for the H2O2
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