Abstract
Electronically modified oxygen derivatives (EMODs), such as superoxide anion and hydrogen peroxide, carry out highly sophisticated intra, inter and extra cellular signaling roles that are essential for normal biochemical functioning. Hydrogen peroxide is freely diffusible through cell membranes, can not be excluded from cells and is required for normal operation of many enzymes that maintain and promote health. Hydrogen peroxide can act as an enzymatic substrate or activate or inhibit redox sensitive enzymes. Large health related organizations, such as the American Cancer Society, continue to disregard and deride the potential beneficial involvement and contribution of EMODs, especially hydrogen peroxide, in the treatment of any disease condition, inclusive of cancer. Their position of disdain is not supported by an exhaustive review of the medical and scientific literature. Although hydrogen peroxide has on occasion been a proposed mutagen, oncogenic transformation primarily leads to an increase of cellular EMODs that renders these same cells selectively vulnerable to additional EMOD production via EMOD induced apoptosis or necrosis. Legitimate medical health agencies are obliged to embrace the widespread scientific supportive findings regarding prooxidant hydrogen peroxide existent in the literature and encourage in depth scientific investigation into prooxidant EMOD disease protection and prevention. Scientific fact must supplant unsupported skepticism or flawed conclusions based on outdated data. While emphasizing hydrogen peroxide, this review is aimed at presenting the scientific facts regarding prooxidant EMOD health applications and cancer therapy. Based on the scientific literature currently available, EMOD use has significant potential benefits in the treatment of a wide range of human pathophysiologies. To deny the crucial role of hydrogen peroxide and prooxidant EMODs in normal metabolic processes and disease protection is to deny scientific truth.
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