Hydrogen membrane transport activity coupled with changing deuterium/hydrogen ratio may be a key proliferation signal for the cells

Somlyai Gábor,Somlyai Ildikó,Laskay Gábor,Gyöngyi Zoltán,Kovács András,Nagy Lajos,Aschner Michael,Krempels Krisztina,Puskás László,Jákli György,Jancsó Gábor,Fábián Gabriella,Ávila Daiana,Guller Imre

doi:10.3389/conf.fphar.2014.61.00044

Abstract

Hydrogen membrane transport activity coupled with changing deuterium/hydrogen ratio may be a key proliferation signal for the cells

Highlights

Background and aimThe deuterium/hydrogen (D/H) mass ratio is the largest among stable isotopes of the same element, causing differences in the chemical behavior between the two hydrogen isotopes
The concentration of D is more than 10 mM (150 ppm) in living organisms, the potential role of D was not investigated for six decades after its discovery
In order to reveal the possible role of naturally occurring D in living organisms, the consequence of the shortage of D was investigated in different biological systems such as cell cultures, animal studies and human clinical trials

Summary

Introduction

Background and aimThe deuterium/hydrogen (D/H) mass ratio is the largest among stable isotopes of the same element, causing differences in the chemical behavior between the two hydrogen isotopes. The concentration of D is more than 10 mM (150 ppm) in living organisms, the potential role of D was not investigated for six decades after its discovery. In order to reveal the possible role of naturally occurring D in living organisms, the consequence of the shortage of D was investigated in different biological systems such as cell cultures, animal studies and human clinical trials.

Results

Conclusion