Abstract
In the title compound [systematic name: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidinium tetrafluoroborate], C14H19N4O3+·BF4−, the trimethoprim (TMP) molecule is protonated at one of the pyrimidine N atoms. The protonated N atom and 2-amine group of the TMP cation interact with the tetrafluoroborate anion through a pair of N—H⋯F hydrogen bonds [graph set R22(8)]. The inversion-related TMP cations are linked through a pair of N—H⋯N hydrogen bonds. The 2-amine group of one TMP cation and the 4-amine group of another cation are bridged by a methoxy O atom, via N—H⋯O hydrogen bonds.
Highlights
Trimethoxybenzyl)pyrimidinium tetrafluoroborate], C14H19N4O3+ÁBF4À, the trimethoprim (TMP) molecule is protonated at one of the pyrimidine N atoms
The inversion-related TMP cations are linked through a pair of N—HÁ Á ÁN hydrogen bonds
The 2amine group of one TMP cation and the 4-amine group of another cation are bridged by a methoxy O atom, via N— HÁ Á ÁO hydrogen bonds
Summary
Madhukar Hemamalini,a Packianathan Thomas Muthiaha* and Daniel E. Lynchb aSchool of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India, and bFaculty of Health and Life Sciences, Coventry University, Coventry CV1 5FB, England. Trimethoxybenzyl)pyrimidinium tetrafluoroborate], C14H19N4O3+ÁBF4À, the trimethoprim (TMP) molecule is protonated at one of the pyrimidine N atoms. 2-amine group of the TMP cation interact with the tetrafluoroborate anion through a pair of N—HÁ Á ÁF hydrogen bonds [graph set R22(8)]. The inversion-related TMP cations are linked through a pair of N—HÁ Á ÁN hydrogen bonds. The 2amine group of one TMP cation and the 4-amine group of another cation are bridged by a methoxy O atom, via N— HÁ Á ÁO hydrogen bonds
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