Abstract
<p indent=0mm>Ionic liquids (ILs) have shown great application potential and drawn broad interests in the field of biomedicine. Despite some important progress, the study of the bio. compatibility and the structure-activity relationship of ILs has just started, and the mechanism is completely unclear, which is a bottleneck in its biological applications. The hydrogen-bonds between ions have become the molecular basis for revealing the biological mechanism. This work introduces the latest development of ILs in biomedicine fields by three typical examples, DNA stabilization, anti-tumor therapy, and API-ILs drug synthesis, recrystallization and release, and details the principle and pathological effects of the hydrogen-bonds. These conclusions can provide knowledge basis for the development of new ILs biomedicine applications.
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