Hydrogen-Bond-Controlled Formal Meta-Selective C-H Transformations and Regioselective Synthesis of Multisubstituted Aromatic Compounds.

Abstract

The meta-selective introduction of functional groups into aromatic substrates was successfully achieved by hydrogen-bond-controlled meta-selective C-H borylation and successive conversion of the boryl group to other functional groups. By this method a wide range of functional groups could be introduced without isolation of the borylated intermediates. The desired meta-functionalized aromatic products were obtained in a one-pot manner even on a gram scale. Regioselective synthesis of multisubstituted aromatic compounds was also achieved.