Abstract
The present study describes the synthesis and characterization of dextran hydrogels produced by photocrosslinking of dextran chains. The hydroxyl groups of native dextran were converted to acrylate groups to make hydrogel precursors with different substitution degrees. The hydrogels were photopolymerizated in the presence of a suitable photoinitiator system (thionine/triethylamine) and characterized by 13C,1H NMR, and infrared spectroscopy. The information about microenvironment formed in hydrogel solutions was obtained by fluorescence spectroscopy using pyrene and nabumetone probes. This technique was used also to study the crosslinking process. The results about the solubility and swelling index data of hydrogels showed that their use as models of drug delivery is technically feasible.
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