Hydrogels from scleroglucan and ionic crosslinkers: Characterization and drug delivery

Abstract

The polysaccharide scleroglucan (Sclg), exploited as a matrix suitable for modified drug delivery, was crosslinked in the presence of three ions: borate, aluminum, and iron. A rheological investigation indicated the main differences between the hydrogels in their viscoelastic linear response: the Sclg/borax system showed the highest strength when deformed by elongation, whereas the strength of the other systems broke down, in terms of viscosity, at much lower values of the imposed strain. Tablets prepared from the gels showed remarkable differences in their water uptake and dimensional swelling. On the other hand, the tablets, loaded with drugs of different steric hindrances, showed similar release behavior, regardless of the crosslinking agent. Scanning electron microscopy analysis was related to the delivery and rheological profiles. Texture analysis, carried out on tablets swollen for 5 h, showed different values of cohesion. Furthermore, when the generalized Maxwell model was applied to the relaxation data, the obtained mechanical spectra showed a more pronounced solidlike character of the Sclg/iron network in comparison with the prevailing viscous behavior of the other matrices. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010