Hydrogels containing water soluble conjugates of silver(i) ions with amino acids, metabolites or natural products for non infectious contact lenses

C N Banti,M Kapetana,C Papachristodoulou,C P Raptopoulou,V Psycharis,T Mavromoustakos,S K Hadjikakou,P Zoumpoulakis

doi:10.1039/d1dt02158c

Abstract

The silver(i) complexes of glycine, urea and salicylic acid were dispersed in poly-hydroxyethyl-methacrylate to form new biomaterials. Their bioactivity makes them efficient candidates for the development of antimicrobial contact lenses.

Highlights

The use of soft contact lenses is a popular method for correcting eye refractive errors.[1]
The inhibition zones which were developed in agar plates of P. aeruginosa, E. coli, S. epidermidis and S. aureus microbes around the pHEMA@AGGLY-2, pHEMA@AGU-2 and pHEMA@AGSAL-2 discs suggest mild antimicrobial activity (Table 1 and Fig. 8)
Since the contact lens wear can be implicated with the occurrence of microbial keratitis (MK), novel active biomaterials pHEMA@AGGLY-2, pHEMA@AGU-2, and pHEMA@AGSAL-2 were synthesised by the dispersion in pHEMA of the known water soluble silver(I) covalent polymers AGGLY, AGU and AGSAL of the natural products GlyH, U and SalH2

Summary

Introduction

The use of soft contact lenses is a popular method for correcting eye refractive errors.[1]. The discs of pHEMA, pHEMA@AGGLY-2, pHEMA@AGU-2, pHEMA@AGSAL-2, were placed in tests tubes with the bacterial strains P. aeruginosa, S. epidermidis and S. aureus (Fig. 5).

Results

Conclusion