Abstract
Bacterial infection has become a serious clinical challenge and a great threat to human health due to antibiotic resistance. Therefore, developing new antimicrobial agents are essential. It is noteworthy that the new antibacterial strategy, photocatalytic antimicrobial therapy, addresses the issue of bacterial resistance. Metal oxides, particular tin oxide, hold great promise in the photocatalytic antimicrobial properties. In addition, noble metal Ag has an excellent improvement effect on the visible light photocatalytic activity of photocatalyst. However, the pure Ag has some shortcomings, such as instability at high temperature. Here, Ag3Sn intermetallic compounds are synthesized, wherein the tin atoms are naturally oxidized to SnOx in the air. The composites (Ag3Sn-SnOx) possess a narrow band gap energy, rendering it suitable as a photocatalytic material responsive to visible light. Meanwhile, Ag3Sn-SnOx will slowly release Ag and play a long-term antibacterial effect. In addition, carboxymethyl chitosan-hyaluronic acid hydrogel are synthesized via amidation reaction, and Ag3Sn-SnOx is loaded into the hydrogel (Ag3Sn-SnOx@Gel), which is also endowed with ability to promote the proliferation and migration of fibroblasts. Coupled with its good biosafety profile, Ag3Sn-SnOx@Gel is expected to emerge as a reliable and effective alternative to the currently used clinical wound dressings.
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