Abstract
New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process.
Highlights
In recent years, significant progress has been made in the field of biology, medicine and materials science, which has led to the development of innovative systems, including films, hydrogels and micro- and nanoparticulate systems based on natural/synthetic polymers as drug carriers
A first important step in the design of a hydrogel type system is represented by the selection of precursors and the method of preparation, which strongly influences the speed and mechanism of the release of bioactive compounds encapsulated in the hydrogel
These results suggest that samples F1 and F6 are more effective as drug delivery systems that are capable of encapsulating a large amount of MT and releasing it effectively
Summary
Significant progress has been made in the field of biology, medicine and materials science, which has led to the development of innovative systems, including films, hydrogels and micro- and nanoparticulate systems based on natural/synthetic polymers as drug carriers. The advantages of such drug delivery systems are the improved therapeutic efficacy of drugs and reduced side effects and associated costs [1,2,3]. Polysaccharides present important advantages as they can be obtained from various natural renewable resources (ocean and plant) and they present an abundance of functional groups, such as hydroxyl (-OH), amino (-NH2) and carboxyl (-COOH), that make them suitable for chemical modification in order to adjust certain properties, biocompatibility, bioactivity and nontoxicity [5]
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