Abstract
Wounds have become one of the causes of death worldwide. The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds that bring great pain to patients, and there is currently no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal dressing candidate because of its 3D structure, good permeability, excellent biocompatibility, and ability to provide a moist environment for wound repair, which overcomes the shortcomings of traditional dressings. This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. Finally, the development prospects and challenges of hydrogel wound dressings are discussed.
Highlights
Masood et al prepared CS-Polyethylene glycol (PEG) hydrogels containing AgNPs by ion cross-linking, the results showed that hydrogels had good antibacterial activity, which could effectively prevent bacterial damage to cells, so as to promote wound healing
Hydrogel dressings are beneficial to the treatment to the wound when they are removed
Hydrogel dressings are beneficial to the treatment of any type of wound
Summary
The skin is the main defense system of the human body, which can protect the human body from microbial infection and external environmental damage [1,2]. Wound dressings are essential for wound healing as they provide a physical barrier between the wound and the external environment to prevent further injury or infection [3] Traditional dressings such as gauze may adhere to the newly grown granulation tissue and cause pain when removed. As hydrophilic gels with 3D network structures, generally have good biodegradability, biocompatibility, adhesion, air permeability, and maintain a moist environment for cell migration, which can effectively promote cell proliferation and facilitate wound healing [15]. These characteristics described above make hydrogels an ideal candidate product for wound dressings [16]. The development prospects and challenges of hydrogels are discussed
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