Abstract
The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements. TKP2 was the optimum formulation as it had a short floating lag time (FLT < 30 s) and more than 98.5% drug release in 12 h. The dissolution data were fitted to popular mathematical models to assess the mechanism of drug release, and the optimum formulation showed a predominant first order release and diffusion mechanism. It was concluded that the TKP2 prepared using tamarind kernel powder:xanthan (4:1) was the optimum formulation with shortest floating lag time and more than 90% release in the determined period of time.
Highlights
Polymers are macromolecules composed of a large number of repeating monomer units
Hydrogel polymers in combination with gas generating agents are commonly used in the development of floating matrix tablets [14]
The results showed that the spectrum of Tamarind Kernel Powder (TKP) resembled that of Tamarind Seed Powder (TSP) spectrum, indicating that the chemical structure of the powders obtained from husked and de-husked seeds is same
Summary
Polymers are used as additives in the manufacturing of dosage forms containing pharmacologically active molecules. They play an important role in different pharmaceutical dosage forms as diluents, binders, disintegrants, gelling agents, thickening agents, emulsifying agents, suspending agents, sustained release agents, stabilizers and coating materials. Natural polymers are usually polysaccharides and are widely used as excipients in oral drug delivery dosage forms. These natural materials have advantages over synthetic polymers, since they are chemically inert, nontoxic, less expensive, biodegradable, widely available, have less chance of adverse effects and have better patient acceptance [2]. Gums are considered to be pathological products formed following an injury to the plant or as a result of some pathological condition, while mucilages are physiological and normal products of metabolism [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
