Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors: A Systematic Review

Abstract

The limitations and negative effects of current therapeutic techniques for brain tumors necessitate the selection of alternative therapeutic options. Therapeutic hydrogel systems that are monitored by magnetic resonance imaging (MRI) are one alternative for neurosurgical treatment of brain tumors that does not need any invasive procedures. There is a significant deal of potential for the treatment of brain tumors that can be attributed to the specific physical and chemical properties that hydrogels possess. The ability to encapsulate therapeutic molecules, provide regulated and sustained drug release, and successfully pass the blood-brain barrier are some of the properties that are included in this category. By combining hydrogel systems with magnetic resonance imaging (MRI) capabilities, it is possible to design therapeutic approaches that provide regulated release of therapeutic medications and real-time monitoring possibilities. Despite the fact that surgical resection is still extremely important, there is a growing demand for alternatives that can supplement or even replace it. Within the scope of this narrative review, the therapeutic hydrogel systems that are monitored by magnetic resonance imaging (MRI) will be evaluated to determine their potential for the non-surgical treatment of brain tumors.