Hydrogel‐Assisted Electrokinetics for High‐Resolution and Non‐invasive Flow Monitoring in Microfluidic Chips†

Abstract

Comprehensive SummaryConvenient non‐invasive flow monitoring would facilitate the operation and control in microfluidic chips, but is challenging due to the small space of microchannels and complex operation required in traditional optical methods. In this work, we propose a novel non‐invasive strategy to probe microfluidic flows via streaming potential phenomenon. By sealing one side of the microchannel with a piece of hydrogel film, streaming potential inside the channel can be clearly detected by electrodes at outer surface of the hydrogel due to ion diffusion in the hydrogel. Flow is detected without sensors contacting with the internal liquid. Moreover, the electrodes shape like a tiny probe, which can move around mapping the flow distribution in a chip with the spatial resolution of 1 mm and flow rate detection limit of 3 μL·min–1. Bubbles inside the channels can also be detected, due to the fluctuation of streaming voltage when gas‐liquid interface flows through the electrode, showing an easy and potential way for multi‐functional flow monitoring in microfluidic chips.