Abstract
AbstractAndrostene and pregnene derivatives were functionalized by amides with rhodium or binary rhodium–cobalt catalysts. Whereas the Rh–PPh3 catalyzed reaction results in the unsaturated amido‐methylidene derivatives, the rapid hydrogenation of these compounds takes place in the presence of a basic PR3 ligand. Using a binary rhodium–cobalt system, amidocarbonylation of the steroids occurs with high chemo‐ and regio‐selectivity. Our experiments did not support literature reports claiming the essential role of a bimetallic cluster as the active catalyst. Copyright © 2002 John Wiley & Sons, Ltd.
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