Abstract
The present study was designed to evaluate the in vivo effect of Allium sativum (garlic) hydroalcoholic extract on wound healing in rats. For this purpose, 72 mature Wistar rats were divided into four groups (n=18/each) to receive no treatment, placebo, Cicalfate(r), or 2% Allium sativum (AS) extract, administered topically to the wound area, for 21 days. Following the experimental period, tissue samples were dissected out and underwent to histopathological analyses. Fibroblasts, fibrocytes, mast cells, intra-cytoplasmic carbohydrate ratio, neovascularization, collagen deposition, and re-epithelialization were analyzed in all groups. Animals in the treated groups showed significant enhancement in fibroblast, fibrocyte, and mast-cell distribution. Significantly higher neovascularization was observed on day 3 after wound induction in AS-treated animals versus those in the placebo, Cicalfate, and untreated groups (P<0.05). A dose-dependent, significantly higher intra-cytoplasmic carbohydrate storage was observed in treated animals. Our data show that AS promotes wound healing due to its preliminary impact on mast-cell distribution, which enhanced collagen synthesis and upregulated angiogenesis, and shortened the healing process by enhancing the intra-cytoplasmic carbohydrate ratio.
Highlights
From a clinical point of view, wounds are an important challenge
Wound contraction developed in Allium sativumtreated animals
Increased the wound contraction rate compared to the control, placebo-treated, and Cicalfate-treated animals
Summary
The presence of diseases such as diabetes, and inappropriate monitoring can lead to severe impairments of the healing process. This process consists of three different phases: inflammation, proliferation, and remodeling (Hemmati, Mohammadian, 2000; Bairy, Rao, 2001). It is mainly administered to accelerate the wound healing and recovery processes. This cream contains: Water (Agua), Caprylic/ Capric Triglycerides, Mineral Oil (Paraffinum Liquidum), Glycerin, Hydrogenated Vegetable Oil, Zinc Oxide, Propylene Glycol, Polyglyceryl 2 Sesquiisostearate, PEG 22 Dodecyl Glycol Copolymer, Aluminum Sucrose Octasulfate, Aluminum Stearate, Beeswax (Cera Alba), Copper Sulfate, Magnesium Stearate, Magnesium Sulfate, Microcrystalline Wax (Cera Microcristallina), Zinc Sulfate
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