Abstract
Cell motility is crucial to biological functions ranging from wound healing to immune response. The physics of cell crawling on a substrate is by now well understood, whilst cell motion in bulk (cell swimming) is far from being completely characterized. We present here a minimal model for pattern formation within a compressible actomyosin gel, in both 2D and 3D, which shows that contractility leads to the emergence of an actomyosin droplet within a low density background. This droplet then becomes self-motile for sufficiently large motor contractility. These results may be relevant to understand the essential physics at play in 3D cell swimming within compressible fluids. We report results of both 2D and 3D numerical simulations, and show that the compressibility of actomyosin plays an important role in the transition to motility.
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