Abstract
Changes evoked by hydrocortisome administration in the Na +−K +-stimulated ATPase of the chick embryo cerebral hemispheres were investigated. The Na +−K +-stimulated ATPase activity in the homogenates of intact chick embryos was not detectable on day 13, but a rapid increase after this day was observed. The Mg 2+-dependent ATPase activity rose gradually but significantly till day 21 of incubation. Hydrocortisone (20 μg per egg) was found to induce the Na +−K +-stimulated ATPase activity but had no effect on the Mg 2+-dependent ATPase activity of the chick embryo cerebral hemispheres. Different sensitivity of the tissue to the hormone was observed before and after day 13 of incubation. Similar changes in the enzyme activity were demonstrated in the microsomal fraction isolated from the hemisphere homogenates and were correlated with the concentraion of sodium and potassium in the hemispheres. Sensitivity of the Na +−K +-stimulated ATPase increase to actinomycin D and cycloheximide was observed.
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