Abstract
SummaryHydration of sheep has been shown to result in a diuresis which is accompanied by a significant increase in glomerular filtration rate. Antidiuretic hormone has also been shown to cause an increase in glomerular filtration rate, observable only in those sheep where the initial glomerular filtration rate has not been raised by prior hydration.It is suggested that antidiuretic hormone has a two‐fold effect on water excretion–an increase in water loss through its glomerular filtration rate‐augmenting effect and a decrease in water loss through its ability to increase tubular water reabsorption. The diuretic effect of antidiuretic hormone frequently observed in non‐hydrated sheep, where glomerular filtration rate initially is low and tubular water reabsorption high, is probably due to a relatively large change in the former and a minor change in the latter of these two effects.
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